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Comparison of human platelet lysate (HPL) and fetal bovine serum (FBS) for optimal culture conditions of neonatal and adult mesenchymal stem cells (MSCs) Freezing and recovery of mesenchymal stem cells in human platelet lysate Applications of Cook human platelet lysate in cell therapy Characterization of human platelet lysate in cytokine analysis and proliferative effect on mesenchymal stem cells Human platelet lysate supports growth of human skin and vascular-derived cells similar to fetal bovine serum and serum-free media Attaching cells to naturally occurring extracellular matrices prior to cell delivery The Role of Human Platelet Lysate in the Cryopreservation of Mesenchymal Stem Cells Evaluation of Stemulate™ for the Expansion and Cryopreservation of Human Mesenchymal Stem Cells Scalable Xeno-Free Expansion of Human Mesenchymal Stromal Cells in a Single-Use, Vertical-Wheel Bioreactor System The Effect of Storage Temperature and Repetitive Temperature Cycling on the Post Thaw Functionality of Human Mesenchymal Stem Cells
Cryopreserved Off-the-Shelf Allogeneic Adipose-Derived Stromal Cells for Therapy in Patients with Ischemic Heart Disease and Heart Failure—A Safety Study (Stem Cells Translational Medicine July 2017)
Rapid and efficient stable gene transfer to mesenchymal stromal cells using a modified foamy virus vector Nathan Paul Sweeney, Cathy Regan, Jiahui Liu, Antonio Galleu, Francesco Dazzi, Dirk Lindemann, C. Anthony Rupar, Myra Olga McClure, , Molecular Therapy accepted article preview online 02 May 2016; doi:10.1038/mt.2016.91
Comparison of clinical grade human platelet lysates for cultivation of mesenchymal stromal cells from bone marrow and adipose tissue Morten Juhl, Josefine Tratwal, Bjarke Follin, Rebekka H. Søndergaard, Maria Kirchhoff, Annette Ekblond, Jens Kastrup & Mandana Haack-Sørensen (2016): Comparison of clinical grade human platelet lysates for cultivation of mesenchymal stromal cells from bone marrow and adipose tissue, Scandinavian Journal of Clinical and Laboratory Investigation, DOI:10.3109/00365513.2015.1099723
Comparative Analysis of Media and Supplements on Initiation and Expansion of Adipose-Derived Stem Cells SIMONE RIIS, FREDERIK MØLGAARD NIELSEN, CRISTIAN PABLO PENNISI, VLADIMIR ZACHAR, TRINE FINK. STEM CELLS TRANSLATIONAL MEDICINE 2016;5:1–11 www.StemCellsTM.com ©AlphaMed Press 2016
Scalability and process transfer of mesenchymal stromal cell production from monolayer to microcarrier culture using human platelet lysate THOMAS R.J. HEATHMAN, ALEXANDRA STOLZING, CLAIRE FABIAN, QASIM A. RAFIQ, KAREN COOPMAN, ALVINW. NIENOW, BO KARA & CHRISTOPHER J. HEWITT. Cytotherapy, 2016; 18: 523–535
Senescence and quiescence in adipose-derived stromal cells: Effects of human platelet lysate, fetal bovine serum and hypoxia REBEKKA HARARY SØNDERGAARD, BJARKE FOLLIN, LISBETH DROZD LUND, MORTEN JUHL, ANNETTE EKBLOND, JENS KASTRUP & MANDANA HAACK-SØRENSEN. Cytotherapy, 2016
Evaluation of human platelet lysate versus fetal bovine serum for culture of mesenchymal stromal cells. Hemeda H, Giebel B, Wagner W. Cytotherapy. 2014 Feb;16(2):170-180.
Pooled human platelet lysate versus fetal bovine serum-investigating the proliferation rate, chromosome stability and angiogenic potential of human adipose tissue-derived stem cells intended for clinical use. Trojahn Kolle SF, Oliveri RS, Glovinski PV, et al..Cytotherapy. 2013 Sep;15(9):1086-1097.
Platelet lysate from whole blood-derived pooled platelet concentrates and apheresis-derived platelet concentrates for the isolation and expansion of human bone marrow mesenchymal stromal cells: production process, content and identification of active components.Fekete N, Gadelorge M, Fürst D, et al. Cytotherapy. 2012 May;14(5):540-554.
Human platelet lysate as a fetal bovine serum substitute improves human adipose-derived stromal cell culture for future cardiac repair applications. Naaijkens BA, Niessen HW, Prins HJ, et al. Cell Tissue Res. 2012 Apr;348(1):119-130.
Peak serum: implications of serum supply for cell therapy manufacturing. Brindley DA, Davie NL, Culme-Seymour EJ, et al. Regen Med. 2012 Jan;7(1):7-13.
Human platelet lysate permits scale-up of dental pulp stromal cells for clinical applications. Govindasmy V, Ronald VS, Abdullah AN, et al. Cytotherapy. 2011 Nov;13(10):1221-1233.
Effect of platelet lysate on the functional and molecular characteristics of mesenchymal stem cells isolated from adipose tissue. Castegnaro S, Chieregato K, Maddalena M, et al. Curr Stem Cell Res Ther. 2011 Jun;6(2):105-114.
Human alternatives to fetal bovine serum for the expansion of mesenchymal stromal cells from bone marrow. Bieback K, Hecker A, Kocaömer A, et al. Stem Cells. 2009 Sep;27(9):2331-2341.
Human platelet lysate can replace fetal bovine serum for clinical-scale expansion of functional mesenchymal stromal cells. Schallmoser K., Bartmann C, Rohde E, et al. Transfusion. 2007 Aug;47(8):1436-46.
Platelet lysates promote mesenchymal stem cell expansion: a safety substitute for animal serum in cell-based therapy applications. Doucet C, Ernou I, Zhang Y, et al. J Cell Physiol. 2005 Nov;205(2):228-236.
Endometrial regenerative cell growth comparison
This is a comparison video of cells grown with Stemulate and FBS